The new mode of action

Different from Minoxidil & Finasteride.

Minoxidil and Finasteride are considered established active ingredients for hair loss – both orally and topically. However, even when applied externally, they can cause unwanted side effects. 8T3 is based on a new active principle that targets the hair root – locally, gently and without affecting the hormonal system.

Eyelash and eyebrow serum next to five hair serum ampoules on a concrete surface in side lighting

Well-known active ingredients. New options.

It's worth comparing.

Minoxidil and Finasteride are among the best-known active ingredients for hair loss – but they are not suitable for everyone. The differences show how important it is to consider the active principles in a differentiated manner.

What can conventional remedies do?

Minoxidil promotes blood circulation, but can cause skin irritation and loses its effect after discontinuation.
Finasteride affects hormone balance, with possible side effects on libido or mood.
Both active ingredients are not suitable for everyone – finasteride is not recommended for women in particular.

8T3 takes a different approach: with the soluble form of the CD83 protein, which acts locally on the hair root – microbiome-friendly, hormone-free, skin irritation-free – for topical use, twice weekly.

Macro shot of a clear gel with air bubbles dripping from a pipette onto a white surface

Principle of action. Effect. Responsibility.

What makes 8T3 different.

8T3 is based on the protein CD83 – in a specially developed, soluble form (MAL-838). The approach is regenerative, scientifically sound, dermatologically supported, and consistently responsible. The differences between 8T3 and its competitors are not only measurable, they are noticeable.


Feature	8T3	Others
Mode of action	Genuine hair regeneration through soluble CD83	Circulation-boosting, hormone-modulating
Formulation	Free from alcohol, hormones, fragrances, and irritants	Synthetic or hormone-active substances, alcohol
Application	Apply locally twice a week, microbiome-friendly and therefore suitable for long-term use	Usually daily; alcohol and daily use can lead to dry and irritated skin

Science, simply explained

How sCD83 acts at the hair follicle.

Which processes does sCD83 influence directly at the hair follicle, and what role do they play in hair growth? The video provides a concise and accessible explanation of how the active ingredient works, offering insight into the scientific mechanism behind 8T3.

Transcript

0:03
The most common causes of hair loss are hormonal factors in androgenetic alopecia, which cause cell death and inflammation of hair follicles, and immune-mediated reactions in alopecia areata, where immune cells attack the hair follicle and cause inflammation.
0:20
Our product is soluble CD83, a molecule naturally expressed by human immune cells.
0:26
When topically applied, sCD83 rapidly diffuses into the hair follicle canal.
0:33
sCD83 activates anti-inflammatory immune cells like regulatory T cells and regenerative macrophages, leading to resolution of inflammation and activation of hair growth.
0:45
sCD83 stimulates macrophages to secrete hair-growth-promoting factors like osteopontin and Wnt, leading to the activation of stem cells.
0:55
In addition, sCD83-activated Tregs as well as sCD83 itself directly bind to hair follicles, inducing the growing phase and expression of keratins, which are the building blocks of hair, and increase hair thickness.
1:11
Our unique mode of action resolves both the hormone- and immune-mediated causes of hair loss, leading to new hair growth.

Row of transparent hair serum ampoules on a stone pedestal, with a round overlay of a shiny molecule rendering

Trust in Science.

8T3 can do that.

Evidence instead of trends
Based on 25 years of scientific research and development.

Microbiome-friendly
Free from alcohol, fragrances, and hormone-active additives — also suitable for sensitive skin.

The future instead of compromise
A new class of active ingredients with a regenerative approach instead of short-term effects.

Studie

Geprüft in der Anwendung. Bestätigt durch Ergebnisse.

8T3 wurde im Rahmen einer unabhängigen Anwendungsbeobachtung mit Personen getestet, die unter sichtbar geschwächtem Haar litten. Die Ergebnisse zeigen: Die innovative Wirkformel von 8T3 kann das Haarbild deutlich verbessern – sichtbar, spürbar und ohne hormonelle Wirkstoffe.

Zur Studie

Two researchers in white lab coats smile and look together at a device next to a microscope

Science as an attitude

Knowledge that comes with responsibility.

For Mallia, science is more than just a method: it is our commitment to openly question developments, share findings transparently, and continuously improve all products. Those who promise results must also be able to prove them – that is why research remains our guiding principle and approach.

The scientific approach

Science Hub

Knowledge that provides support.

In our Science Hub, you can find out what drives our research – and what it means for you. Here, we share new findings, background information on how our products work, and developments in the field of hair regeneration.

21. Jul 2026

Questions – clearly answered.

Would you like to learn more about the new mode of action of 8T3? You will find answers in our frequently asked questions – precisely formulated and carefully compiled.

See all FAQs

Your path to hair regeneration

Perfect eyebrows: shape, care, and methods at a glance

How to get longer eyelashes: What really works – from care to serums

8T3 by Mallia: Safe. Compatible. Certified.